Abstract
BackgroundCyclodextrins are active pharmaceutical ingredients to treat neurological diseases by reducing neurotoxicity. The aim of this study was to test if combined consumption of β-cyclodextrin (BCD) and Oleic acid (OA) potentiates brain antioxidant protection.MethodsFour groups of young Wistar rats, grouped in 6 animals each, were treated as follows: Group (G) 1, saline solution 0.9% (control); G2, BCD (0.7 g/kg); G3, OA (15 ml/kg); G4, BCD + OA. The same design was assayed for groups of adult rats. Treatments were daily administered by oral means for five consecutive days. On the last day of administration, brains of the animals were extracted to measure dopamine, 5-HIAA, glutathione (GSH), ATPase, Lipoperoxidation and H2O2.ResultsOleic acid and β-cyclodextrin upgraded the levels of dopamine, 5-HIAA and lipid peroxidation and downgraded the concentrations of GSH and H2O2 in cortex, hemispheres (striatum) and cerebellum/medulla oblongata regions.ConclusionsThe results of the present study suggest that combined use of oleic acid and β-cyclodextrin may increase oxidative damage in brain regions and promote alteration in dopamine and 5-HIAA amines and hence, constitutes health risks among age of subjects.
Highlights
Cyclodextrins are active pharmaceutical ingredients to treat neurological diseases by reducing neurotoxicity
The purpose of the present study was to compare the combined effect of β-cyclodextrin (BCD) and oleic acid (OA) on selected oxidative stress markers and the levels of dopamine in brain regions of young and adult rat
With the exception of GSH and H2O2 (Figs. 3 and 5) the concentrations of the different indicators were lower for both adult and young animals in the control group when compared with the experimental groups
Summary
Cyclodextrins are active pharmaceutical ingredients to treat neurological diseases by reducing neurotoxicity. The aim of this study was to test if combined consumption of β-cyclodextrin (BCD) and Oleic acid (OA) potentiates brain antioxidant protection. CDs have been found to reduce the neurotoxicity [1], and they are active pharmaceutical ingredients to treat neurological diseases [2]. It has been found that brain aging is accompanied by a Nitric oxide is a good neuromodulator an extra amount of it may lead to cell damage by oxidative stress or by decreasing reduced glutathione levels via nitroso-glutathione (NOGSH) formation within the cell [7]. The purpose of the present study was to compare the combined effect of β-cyclodextrin (BCD) and oleic acid (OA) on selected oxidative stress markers and the levels of dopamine in brain regions of young and adult rat
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