Abstract
Chronic myeloid leukemia (CML) is currently a disease in which patients can enjoy a near normal life-expectancy. However, since the majority of patients will need to remain on treatment indefinitely, physicians in care of CML patients need be familiar with the indications and toxicities of all approved tyrosine kinase inhibitors (TKI). In clinical practice, there are five TKI (imatinib, nilotinib, dasatinib, bosutinib, and ponatinib) that are available in different scenarios and have distinct safety profiles. Decisions regarding first line treatment must be based on CML risk, comorbidities, and patients expectations. Despite the excellent outcome, half of the patients will eventually fail (due to intolerance or resistance) to first line treatment, with many of them requiring a third or even further lines of therapy. When selecting for such patients, it is essential to distinguish between failure and intolerance to previous TKIs. In the present review, we will address all these issues from a practical point of view.
Highlights
The prognosis of chronic myeloid leukemia (CML) has changed during the past two decades from a disease with an overall survival (OS) of 5 years only to one in which patients can enjoy a near normal life-expectancy [1, 2]
It is crucial for physicians caring for CML patients to be aware of which tyrosine kinase inhibitors (TKI) are available for each particular clinical situation, what can be expected from them, and how to manage their potential side effects
Radotinib was approved in Korea for the frontline treatment of CML based on the results of a phase III clinical trial that demonstrated its benefit in MMR rates as compared to imatinib (52 vs. 30% by 12 months)
Summary
The prognosis of chronic myeloid leukemia (CML) has changed during the past two decades from a disease with an overall survival (OS) of 5 years only to one in which patients can enjoy a near normal life-expectancy [1, 2]. Such remarkable improvement in the patients’ outcome is mainly due to the introduction of imatinib into the clinic (the first approved tyrosine kinase inhibitor [TKI]), and to the approvals of others TKIs. Currently, there are five TKIs available for CML treatment in clinical practice (Table 1) [3].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
