Abstract
During the course of screening of medicinal plants of Pakistan for the isolation and structure elucidation of bioactive natural products, it was found that the methanol extract of the Rhododendron collettianum showed analgesic and spasmolytic activities. The methanol extract was then extracted with chloroform. Nine pentacyclic triterpenes were isolated from the chloroform extract and their structures were elucidated as erythrodiol (1), betulinic acid (2), maslinic acid (3), 2alpha,3alpha,23-trihydroxyolean-12-en-28-oic acid (4), bayogenin (5), arjunilic acid (6), methyl arjunolate (7), arjungenin (8) and 3beta, 23, 24-trihydroxyolean-12-en-28-oic acid (9). Among the triterpenes (1-9) tested, arjunilic acid (6) was found to be most potent. Their structure-activity relationship (SAR) showed that if the configuration of the -OH group at C-2 is changed from alpha to beta the potency is decreased. In most of the compounds the position and configuration of the -OH group was found to be important for the inhibitory potency against the enzyme tyrosinase. For the comparison, the standard tyrosinase inhibitors kojic acid (IC50=16.67 microm) and L-mimosine (IC50=3.68 microm) were used as controls.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
