Typhus at Belsen. II. Clinical course of epidemic typhus in persons who had received Craigie typhus vaccine.

Abstract

Article1 February 1951TYPHUS AT BELSEN. II. CLINICAL COURSE OF EPIDEMIC TYPHUS IN PERSONS WHO HAD RECEIVED CRAIGIE TYPHUS VACCINEWILLIAM A. DAVISWILLIAM A. DAVISSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-34-2-448 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBritish troops who took part in the recent war in Europe were inoculated with Craigie typhus vaccine. During the typhus epidemic at Belsen in 1945, at least 14 of them contracted the disease. This provided an opportunity to observe naturally acquired epidemic typhus in persons who had received Craigie typhus vaccine. The primary purpose of this paper is to describe the clinical course of their illness with data on their previous inoculations and serologic responses.In the same epidemic, there were 16 cases of typhus among Hungarian soldiers who were inoculated with Craigie vaccine after exposure to the disease. There...Bibliography1. Zinsser H: Epidemiology and immunity in rickettsial disease, in Virus and rickettsial diseases, 1940, Harvard University Press, Cambridge, pp. 872-907. Google Scholar2. Cox HR: Use of yolk sac of developing chick embryo as medium for growing rickettsiae of Rocky Mountain spotted fever and typhus groups, Pub. Health Rep. 53: 2241-2247, 1938. CrossrefGoogle Scholar3. CoxBell HREJ: Epidemic and endemic typhus: protective value for guinea pigs of vaccines prepared from infected tissues of the developing chick embryo, Pub. Health Rep. 55: 110-115, 1940. CrossrefGoogle Scholar4. Craigie J: Application and control of ethyl ether water interface effects to the separation of rickettsiae from yolk sac suspensions, Canad. J. Research 23: Sect. E, 104-114, 1945. CrossrefGoogle Scholar5. ToppingShear NHMJ: Section III. Studies of antigens in infected yolk sac, U. S. National Institute of Health Bulletin No. 183, 13-16, Washington, D. C., 1945. Google Scholar6. EckeGilliamSnyderYeomansZarafonetis RSAGJCACJ: The effect of Cox-type vaccine on louse-borne typhus fever, Am. J. Trop. Med. 25: 447-462, 1945. CrossrefMedlineGoogle Scholar7. Sadusk JF: Typhus fever in the United States Army following immunization, J. A. M. A. 133: 1192-1199, 1947. CrossrefMedlineGoogle Scholar8. Topping NH: Notes on the preparation of epidemic typhus vaccine, N. I. H. Bulletin No. 183, 30-32, Washington, D. C., 1945. Google Scholar9. CraigieWatsonClarkMalcomson JDWEMME: The serological relationships of the rickettsiae of epidemic and murine typhus, Canad. J. Research 24: Sect. E., 84-103, 1946. CrossrefMedlineGoogle Scholar10. Davis WA: Typhus at Belsen. I. Control of the epidemic, Am. J. Hyg. 46: 66-83, 1947. MedlineGoogle Scholar11. Murchison C: A treatise on the continued fevers of Great Britain, 3rd Edition, 1884, London. Google Scholar12. WolbachToddPalfrey SBJLFW: The etiology and pathology of typhus, 1922, Harvard University Press, Cambridge, Mass. Google Scholar13. SoperDavisMarkhamRiehl FLWAFSLA: Typhus fever in Italy, 1943-1945, and its control with louse powder, Am. J. Hyg. 45: 305-334, 1947. CrossrefGoogle Scholar14. Van den EndeStuart-HarrisFultonNivenAndrewesBeggElfordGleeson-WhiteHawleyMillsHamiltonThomas MCHFJSCHAMWSMHWLKCFCC: Chemotherapeutic and other studies of typhus, Medical Research Council, Special Report Series No. 255, London, H. M. Stationery Office, 1946. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Glen Ridge, N. J.*Received for publication January 27, 1949.From the United States of America Typhus Commission, War Department, Washington 25, D. C.†Formerly Major, M. C., A. U. S.; Consultant on typhus from the United States of America Typhus Commission to the 21st Army Group.It is a pleasure to acknowledge the unfailing coöperation of Lt. Col. M. W. Gonin, D. S. O., R. A. M. C., who collaborated in these studies. I am also indebted to Major C. J. Zarafonetis, M. C., A. U. S., who was responsible for the serologic examinations, to Dr. Ruth Pitt-Rivers, who made the determinations of NPN, and to many at Belsen who helped in the care of typhus patients under epidemic conditions. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByConcepts of Louse-Borne Typhus Control in Developing Countries: The Use of the Living Attenuated E Strain Typhus Vaccine in Epidemic and Endemic SituationsVIRAL VACCINES AND HUMAN WELFARE 1 February 1951Volume 34, Issue 2Page: 448-465KeywordsInoculationPatientsTyphusVaccines Issue Published: 1 February 1951 PDF DownloadLoading ...