Abstract
Typhoid fever developed in six previously immunised Peace Corps Volunteers in India during a 2-year period. Observations on the time-interval between previous typhoid vaccine boosters and the onset of clinical typhoid fever led to a modification of the immunisation schedule in an attempt to reduce the incidence of typhoid fever in the volunteer population. Booster injections were given every 41/2 months. It is suggested that a controlled clinical trial of this modified regimen under field conditions would be worthwhile.
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