Abstract
To determine the seropositivity of typhoid fever in febrile pediatric patients presenting to tertiary care center. This observational study was conducted at Children Hospital Quetta (CHQ) from July 2011 to March 2012. The children with three or more days fever, no obvious focus of infection and clinically suspected of typhoid fever were screened. Sterile Blood samples were obtained from febrile patients and Widal and Typhidot® tests were performed for the diagnosis of Typhoid fever in the suspected populations. Total of 2964 clinically suspected patients were screened for typhoid fever. Of these, 550 (18.6%) patients were positive serologically. The higher prevalence of the disease in hot summer season and increasing pattern of the disease was observed in summer days. The disease was higher in school age children under 5-10 years. Although non-significant association was observed on sex basis. The findings highlight the considerable burden of typhoid fever in pre-school and school-aged children. The variation in the disease pattern has also been observed under seasonal variation and different age groups, all of which need to be considered in deliberations to control the typhoid fever.
Highlights
A total of 2946 patients clinically suspected for enteric fever were subjected to evaluation for typhoid fever using Widal (n=1526 Patients) and typhoid test (n=1420 patients)
Five hundred and fifty patients were positive with overall prevalence of 18.66%
Out of 354 suspected patients, only 16 (4.5%) were positive in the age group 0-1 year whereas in 1-5 years age a total of 1261 patients were screened for typhoid fever and 216 were found positive with 17.12% prevalence
Summary
To determine the seropositivity of typhoid fever in febrile pediatric patients presenting to tertiary care center. The children with three or more days fever, no obvious focus of infection and clinically suspected of typhoid fever were screened. Sterile Blood samples were obtained from febrile patients and Widal and Typhidot® tests were performed for the diagnosis of Typhoid fever in the suspected populations. Results: Total of 2964 clinically suspected patients were screened for typhoid fever. The higher prevalence of the disease in hot summer season and increasing pattern of the disease was observed in summer days. The disease was higher in school age children under 5-10 years. Conclusion: The findings highlight the considerable burden of typhoid fever in pre-school and schoolaged children. The variation in the disease pattern has been observed under seasonal variation and different age groups, all of which need to be considered in deliberations to control the typhoid fever
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