Abstract
Purpose: Ipsilateral-breast-local-recurrence (ILBLR) is a rare event with little data on immediate-breast-reconstruction (IBR). We report post-operative results of different types of mastectomy for ILBLR with or without IBR performed during a period of 40 months in order to analyze post-operative complications as main objective.Methods: We analyzed mastectomies performed for ILBLR after initial breast conservative treatment from January 2016 to April 2019. The characteristics of patients, surgery, complication rate, postoperative hospitalization have been determined.Results: Of the 207 mastectomies, 32.8% had an IBR: 31 nipple-sparing-mastectomy (NSM) and 37 skin-sparing-mastectomy (SSM) with 37 latissimus-dorsi-flap (LDF) IBR and 31 implant-IBR. Few reconstruction was performed for patients with body-mass-index ≥30 (OR = 0.214), infiltrating ductal carcinomas (OR = 0.272) and ASA-3 patients (OR = 0.254). In multivariate analysis, LDF-IBR was more often realized for NSM and for patients with BMI ≥25. The overall complication rate was 37.4%: 45.6 and 33.1% with and without IBR, respectively (p = 0.056). In multivariate analysis, BMI ≥25 (OR 2.02, p = 0.023), IBR (OR 1.9, p = 0.046) and tobacco (OR 2.17, p = 0.055) were correlated with higher risk of complications. There was no difference for Grade 2–3 complications rates for IBR and no IBR, respectively (14.7%: 10/68 and 9.3%: 13/139). In multivariate analysis, overall survival from date of mastectomy for local recurrence was significantly associated with interval time to local recurrence (OR 6.981).Conclusion: Salvage mastectomy and IBR is a good choice for ILBLR, particularly using flap reconstruction. NSM can be considered as a good option in selected patients for ILBLR for NSM and/or LDFR.
Highlights
The ipsilateral breast local recurrence (ILBLR) appears after breast conserving treatment (BCT), defined as breast-conserving surgery followed by whole-breast radiation therapy
The main objective of our study was to determine the effects of previous radiotherapy on surgical outcomes after mastectomy performed for ILBLR with or without immediate breast reconstruction (IBR)
Characteristics of patients with total mastectomy for ILBLR with or without IBR were reported on Table 1
Summary
The ipsilateral breast local recurrence (ILBLR) appears after breast conserving treatment (BCT), defined as breast-conserving surgery followed by whole-breast radiation therapy. Metastatic disease in the internal mammary, supraclavicular, infraclavicular, or ipsilateral axillary nodes was classified as a regional recurrence. In 2017, the rate of locoregional recurrences was 8.2% after BCT in very young woman (women
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