Abstract
BackgroundSchizophrenia (SC) and bipolar disorder (BD) are among the most devastating diseases worldwide. There are several lines of evidence suggesting that viruses may play significant roles in the etiology of these mental disorders. The aim of this study was the detection of HHV-6A/B in the peripheral blood mononuclear cells (PBMC) of SC and BD patients versus the healthy control (HC) subjects using a new method of type-specific Real time PCR analysis.MethodsA type-specific Real time PCR was performed for simultaneous detection and typing of HHV-6A/B in the PBMCs of 120 SC and BD patients and 75 HCs.ResultsOnly one case of HHV-6B out of 120 (0.8 %) SC and BD patients and two cases of HHV-6A (2.7 %) in 75 HCs were detected.ConclusionsThe low levels of HHV-6 detection in PBMCs, severely limited the capacity of this study to investigate the association between the presence of HHV-6 and BD or SC in this population, thus no conclusions can be drawn in this regard. Meanwhile this study introduces a Real time PCR based method for type specific detection of HHV-6A/B in clinical samples.
Highlights
Schizophrenia (SC) and bipolar disorder (BD) are among the most devastating diseases worldwide
As human herpes virus 6 (HHV-6) is predominantly a T-cell tropic virus, the purpose of this study was the detection of HHV-6A/B in the peripheral blood mononuclear cells (PBMC) of SC and BD patients versus the healthy control (HC) subjects using a type specific Real time Polymerase chain reaction (PCR) analysis
Type specific Real time PCR A total of 120 patients (60 SC and 60 BD) and 75 HCs were included in this study
Summary
Schizophrenia (SC) and bipolar disorder (BD) are among the most devastating diseases worldwide. There are several lines of evidence suggesting that viruses may play significant roles in the etiology of these mental disorders. Schizophrenia (SC) and bipolar disorder (BD) are debilitating mental illnesses distributed worldwide. Various factors have been implicated in the etiology and pathogenesis of these major mental disorders. There is controversial evidence to indicate that infectious organisms might have a role in affecting the etiologic pathways implicated in psychiatric diseases such as SC and BD [1]. Herpes viruses have been supposed as the key pathogenic factors in mental diseases [3]. The human herpes virus 6 (HHV-6) was first isolated in 1986 by Salahuddin and coworkers [4, 5].
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