Abstract
Dietary protein plays an important role in the regulation of lipogenesis in liver and secretion of insulin by pancreas, however it is not known whether the type of protein exerts an effect in adipose tissue functionality. Thus, the aim of this study was to analyze the gene expression pattern of adipose tissue in obese rats fed casein or soy protein diet. Results indicate that adipose tissue from retroperitoneal fat pads of rats fed soy protein presented a significant decrease in the expression of leptin, tumor necrosis factor alpha and its receptor, angiotensinogen, genes involved in inflammatory response, genes of signaling mediators and genes involved in cholesterol metabolism compared with rats fed casein diet. These results suggest that soy protein improves adipose tissue functionality in a model of diet induced obesity. This work was supported by grant # 46135M, CONACYT.
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