Abstract
We measured urinary albumin (U-Alb) and type IV collagen (uIV·C) in spot urine collected from 82 patients with non-insulin-dependent diabetes mellitus (NIDDM) and 205 controls. Eighty-two NIDDM patients that had no increased excretion of either U-Alb or uIV·C were observed for 6 months. Prevalence of increased excretion of U-Alb and uIV·C at 6 months in these patients were 32.9%, and 62.2%, respectively. Increased excretion of uIV·C was detected in 27 patients without microalbuminuria. χ 2 analysis suggested that uIV·C was more sensitive than U-Alb, and that hypertension enhanced increased excretion of both U-Alb and uIV·C. uIV·C was significantly correlated ( P<0.01) with U-Alb but not glycosylated hemoglobin A1C (HbA1C) in NIDDM patients. Taken together, uIV·C may be a useful marker for early diabetic nephropathy.
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