Abstract

BackgroundCutis laxa is a connective tissue disease characterized by loose, wrinkled, and redundant skin. It is either inherited or acquired. In most cases, acquired cutis laxa is associated with neoplasms, drugs, and autoimmune diseases. We present a rare case of acquired cutis laxa following a recurrent urticaria-like eruption in the absence of an autoimmune disease, neoplasm, drugs and or syndrome.Case presentationWe report a case of a 45-year-old Chinese lady with a 1-year history of widespread pruritic urticarial eruption and a 6-month history of progressive skin wrinkling. On examination, the patient appeared older than her actual age, with apparent wrinkling on the mid-torso with generalized smooth, erythematous macules and wheals. A family history of similar conditions was absent. Biopsy revealed hypersensitivity and atrophy. Following the Food and Drug Administration (FDA) guidelines, we administered antihistamines, which relieved the itching, but her hyperpigmentation and cutis laxa never improved.ConclusionOur case shows that the decrease of elastic fibers may be associated with the infiltration of inflammatory cells in the dermis. This supports the hypothesis that chemical mediators may play a major role in the destruction of elastic fibers, thus causing cutis laxa. In addition, we advise practitioners to take a complete clinical and family history to determine if the condition is inherited or acquired.

Highlights

  • Cutis laxa is a connective tissue disease characterized by loose, wrinkled, and redundant skin

  • This supports the hypothesis that chemical mediators may play a major role in the destruction of elastic fibers, causing cutis laxa

  • We advise practitioners to take a complete clinical and family history to determine if the condition is inherited or acquired

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Summary

Conclusion

Our case shows that the decrease of elastic fibers may be associated with the infiltration of inflammatory cells in the dermis.

Background
Discussion and conclusion
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