Type B Progesterone Receptor Polymorphism Increases the Risk of Pelvic Organ Prolapse in Balinese Women

Abstract

This study aims to determine the role of type B progesterone receptor gene polymorphisms as a risk factor for pelvic organ prolapse in Balinese women. This paired case-control study involves 29 patients with pelvic organ prolapse as the case group and 29 patients without pelvic organ prolapse as the control group. The study was conducted at Sanglah Hospital, Denpasar and the Integrated Biomedical Laboratory, Faculty of Medicine, Udayana University. Three milliliters of venous blood samples were taken from each patient and PCR examination was performed to determine the type b progesterone receptor gene polymorphisms. Risk assessment of the type b progesterone receptor gene polymorphism for pelvic organ prolapse was done by controlling for confounding variables, including age, parity, body mass index, occupation, menopausal status, and history of hysterectomy, through multiple logistic regression tests. The type b progesterone receptor gene polymorphism increased the risk of pelvic organ prolapse three times compared to non-prolapsed in Balinese women (OR 3.90, 95%CI 1.16-13.07, p = 0.023). After controlling for various confounding variables, type b progesterone receptor gene polymorphism still increased the risk of pelvic organ prolapse up to four times (AOR 4.54, 95%CI 1.16-17.68, p = 0.029). The type b progesterone receptor gene polymorphism significantly increases the risk of pelvic organ prolapse in Balinese women.