Abstract
Normal 0 false false false EN-US X-NONE X-NONE Mucoadhesive test of polymer excipient is important for development of oral sustained release dosage form in mucoadhesive system to increase bioavailability of a drug. The study focused on mucoadhesive strength of gelatinus granules in stomach and intestine of rat using bioadhesive and wash off tests. Gelatin is a substance obtained from partially hydrolyzed collagen of skin, white cattle bones and animal bones. Gelatin derived from acid process is called type A gelatin and those from alkali process is called type B gelatin. This research studied the influence of various gel strength of type B gelatins, particularly their mucoadhesive characteristics. Mucoadhesive tests were performed at the concentration of 7.14%, 3.66%, and 2.45% and with gel strength of 328 g Bloom, 230 g Bloom and 119 g Bloom respectively. The results showed that granules formula with 230 g Bloom gel strength showed the best mucoadhesive strength, with adhesion percentage of 100%.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
