Abstract

Aims:To evaluate the prevalence and risk factors oftype 2diabetes mellitus (T2DM)from 2000-2020invarious parts ofNepal. Methods:PubMed, Embase, Scopus, and Google Scholar were searched using the appropriate keywords. All Nepalese studies mentioning the prevalence ofT2DMand/or details such asrisk factors were included. Studies were screened using Covidence. Two reviewers independently selected studies based on the inclusion criteria. Meta-analysis was conducted usingComprehensive Meta-AnalysisSoftwarev.3. Results:Total 15 studies met the inclusion criteria. The prevalence ofT2DM, pre-diabetes, and impaired glucose tolerance in Nepal in the last two decades was 10% (CI, 7.1%- 13.9%), 19.4% (CI, 11.2%- 31.3%), and 11.0% (CI, 4.3%- 25.4%) respectively. The prevalence ofT2DM in the year 2010-15 was 7.75% (CI, 3.67-15.61), and it increased to 11.24%between 2015-2020(CI, 7.89-15.77). There were 2.19 times higher odds of havingT2DMif the body mass index was ≥24.9 kg/m 2. Analysis showed normal waist circumference, normal blood pressure, and no history ofT2DM inafamilyhas64.1%, 62.1%, and 67.3%lower odds ofhaving T2DM,respectively. Conclusion:The prevalence ofT2DM, pre-diabetes, and impaired glucose tolerance in Nepal was estimated to be 10%, 19.4%, and 11% respectively.

Highlights

  • In 2019, the International Diabetes Federation (IDF) estimated that 463 million adults worldwide had diabetes[1]

  • IDF estimates that the global prevalence of diabetes will be 578.4 million by 2030, with this rising to 700.2 million by 2045 among adults aged between 20 to 79 years[1] In the region of Southeast Asia, the prevalence of diabetes was 8.8% in 2019, and this is projected to increase to 9.7% by 20302

  • Type 2 diabetes mellitus (T2DM) still remains a major cause of worldwide morbidity and mortality, which leads to complications such as neuropathy, nephropathy, stroke, and coronary artery disease[3]

Read more

Summary

Introduction

In 2019, the International Diabetes Federation (IDF) estimated that 463 million adults worldwide had diabetes[1]. IDF estimates that the global prevalence of diabetes will be 578.4 million by 2030, with this rising to 700.2 million by 2045 among adults aged between 20 to 79 years[1] In the region of Southeast Asia, the prevalence of diabetes was 8.8% in 2019, and this is projected to increase to 9.7% by 20302. There have not been many studies that evaluate the risk factors of T2DM in Nepal, which can be helpful for the prevention and control of this disease. We conducted this review to evaluate the prevalence and risk factors of pre-diabetes and T2DM in Nepal over the past 20 years, by pooling the studies done in various parts of the country. Doing a meta-analysis using a small number of studies might cause bias

Methods
Results
Discussion
Conclusion

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.