TYPE 2 DIABETES

Abstract

Objectives: To determine the prevalence and the associated risk factors ofNAFLD in Type 2 diabetic patients. Study Design: Cross sectional study. Setting: Diabeticclinic of Medical Unit 3, JPMC. Methods: It is a cross sectional study. 262 patients wereenrolled between the ages of 18-70 years attending Diabetes Clinic of Medical Unit III, JPMC.Each consenting patient underwent a detailed medical history-taking, physical examination,laboratory assessment and abdominal ultrasonography (US). Fatty liver was diagnosed onabdominal US on the basis of two out of the three criteria: increased hepatic echogenicity,blurring of liver vasculature and deep attenuation of the ultrasonographic signal. In accordancewith the guidelines, subjects diagnosed with NAFLD had to fulfill the following criteria: nohistory of current or past alcohol consumption, other systemic illness known to cause fatty liverdisease; absence of history and clinical, biochemical and US findings consistent with cirrhosis.Body mass index (BMI) was calculated. Blood pressures of greater than 130/90 were takenas hypertensive. LFTs, FBS, HbA1c, Lipid profiles were taken. Results: Out of 262 diabeticpatients 107 (40.8%) of them were found to be having NFALD. Prevalence was found out to behigher in age group of 41-50 years, females, obese & in Pashtoon subjects.It was also moreprevalent in sedentary lifestyle patients and those on oral anti diabetics in contrast to insulintherapy. It was correlating well with US findings when the ALT cut-off value was taken as 30 IUfor males and 19 IU for females compared to standard values of ALT. There was associationwith hypertension, metabolic syndrome and dyslipidemia. Conclusion: Prevalence of NAFLDwas higher in our diabetic patients. Middle age, female gender and obesity were found to bestatistically strong risk factors in our study.