Abstract
Vitamin D (Vitamine D), classically recognized as an important player in bone and phosphocalcic metabolism, has shown, through recent studies, its involvement in the pathogenesis of insulin resistance in case of deficiency. The aim of this work is to describe the profile of vitamin D in a type 2 diabetic population and to correlate the vitamin D status with the different metabolic parameters in this population admitted in the University Hospital of Marrakech. It is a descriptive cross-sectional study of a population of type 2 diabetic patients, coming for a follow-up assessment of diabetes and having performed an evaluation of the level of 25 hydroxy vitamin D3 in blood. Demographic, clinical, evolutionary and biological data were collected. The mean of 25 (OH) vitamin D3 was 12.55 ± 8.14 ng / ml for the group, and was 13.15 ± 8.93 ng / ml for women and 11.82 ± 7.31 ng / ml for men. These patients were classified into three groups: Group 1: 25 (OH) D 30 ng / ml present in 4 patients in this population (4, 8%). Several studies have reported an association between vitamin D status and the development of type 2 diabetes. Experimental studies have suggested that vitamin D deficiency decreases insulin sensitivity, carbohydrate tolerance and β-pancreatic function. The data of this work underline the high frequency of vitamin D deficiency in the Moroccan population suffering from type 2 diabetes.
Highlights
Vitamin D (Vitamin D) has long been considered an essential hormone for regulating phosphocalcic metabolism and bone mineralization
This insulin resistance is a major risk factor for diabetes contributing to its pathogenesis and decreased glucose tolerance [2,3,4]
The concomitant association of vitamin D deficiency with insulin resistance and their important metabolic consequences has led to the hypothesis of a possible role of vitamin D in the pathogenesis of type 2 diabetes [1]
Summary
Vitamin D (Vitamin D) has long been considered an essential hormone for regulating phosphocalcic metabolism and bone mineralization. The progression of the fundamental and clinical knowledge made it possible to conclude to its implication in the pathogenesis of insulin-resistance in the event of deficiency [1]. This insulin resistance is a major risk factor for diabetes contributing to its pathogenesis and decreased glucose tolerance [2,3,4]. The concomitant association of vitamin D deficiency with insulin resistance and their important metabolic consequences has led to the hypothesis of a possible role of vitamin D in the pathogenesis of type 2 diabetes [1]. The purpose of this work is to describe the blood levels of vitamin D in a population of type 2 diabetes patients referred to the Marrakech University Hospital Center for assessment and to establish a correlation between the status of vitamin D and the various metabolic parameters, as well as degenerative complications in this population
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