Abstract

Deiodinase is a selenoproteinase, including type 1 deiodinase (D1), type 2 deiodinase (D2) and type 3 deiodinase (D3), which plays an important regulatory role in the metabolism of thyroid hormone. D2 plays an important role in the transformation from T4 to T3, from rT3 to T2. There are two types of ubiquitination ligases such as WSB1 and TEB4, and two deubiquitination enzymes such as USP20 and USP33, involved in the process of D2 ubiquitination. D2 plays an important role in the regulation of thyroid hormone by hypothalamic-pituitary-thyroid axis (HPT), and plays an important role in hypothyroidism and its treatment. Its expression is also related to medullary thyroid cancer. D2 ubiquitination also involves in the elevation of thyroid stimulating hormone induced by chronic iodine overdose. Meanwhile, D2 gene polymorphism is involved in the metabolism of thyroid hormone and affects the level of thyroid hormone. Key words: Ubiquitin proteasome pathway; Type 2 deiodozyme; Hypothalamic-pituitary-thyroid axis; Ubiquitination ligase; Deubiquinase

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