Abstract
Severe sepsis is a systemic host response to invading pathogen with activated inflammation, coagulation and tissue remodelling cascades and consequent organ dysfunction. Despite modern intensive care, mortality in severe sepsis remains high. Mesenchymal stromal cells (MSCs) are known to have many anti-inflammatory features and contribute to the healing process. Many research groups have demonstrated good results using MSCs as an adjunctive treatment of sepsis in animal studies. Recently, a research group conducted a phase I clinical trial to test safety of MSCs on ARDS patients ([1]). To date knowledge of sepsis influence on MSCs is scarce.
Highlights
Severe sepsis is a systemic host response to invading pathogen with activated inflammation, coagulation and tissue remodelling cascades and consequent organ dysfunction
PINP concentration was determined with a chemiluminescence immunoassay (IDS iSYS, Immunodiagnostics Systems, Boldon, UK) and PIIINP concentration was determined with a radioimmunoassay (Orion Diagnostica, Espoo, Finland)
In all BM-Mesenchymal stromal cells (MSCs) lines, and repeated experiments (n = 6), production of both PINP and PIIINP were suppressed in the sepsis group (p < 0.001 both PINP and PIIINP)
Summary
Severe sepsis is a systemic host response to invading pathogen with activated inflammation, coagulation and tissue remodelling cascades and consequent organ dysfunction. Mesenchymal stromal cells (MSCs) are known to have many anti-inflammatory features and contribute to the healing process. Many research groups have demonstrated good results using MSCs as an adjunctive treatment of sepsis in animal studies. A research group conducted a phase I clinical trial to test safety of MSCs on ARDS patients ([1]). To date knowledge of sepsis influence on MSCs is scarce
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