Abstract

Two-fold unsymmetrical functionalization of arenes, which includes sequential halogenation/oxygenation reactions, has been developed. This transformation allows for a general and efficient synthesis of substituted meta-halophenols from simple aryl iodides. Importantly, the PyrDipSi (2-diisopropylsilylpyrimidine) group can be easily removed or efficiently converted into valuable functionalities.

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