Abstract
A pair of new mononuclear zinc(II) complexes with hydrazone ligands 4-methoxybenzoic acid (1-pyridin-2-ylmethylidene)hydrazide (HLa) and benzoic acid (1-pyridin-2-ylethylidene)hydrazide (HLb) were prepared. They are [Zn(La)2] (1) and [Zn(Lb)2] (2). The complexes were characterized by physico-chemical methods and single crystal X-ray determination. The tridentate hydrazone ligands coordinate to the Zn atoms through the pyridine nitrogen, imino nitrogen and enolate oxygen atoms. The Zn atom in each complex is six coordinated by two hydrazone ligands, to form octahedral coordination. The complexes have effective activities against the bacteria Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas fluorescens.
Highlights
Schiff bases are readily synthesized by the condensation reaction of aldehydes with primary amines, which have been widely investigated for their antibacterial and antitumor activities.[1]
The complexes were readily prepared by the reaction of the Schiff bases and zinc nitrate in methanol (Scheme 2)
The dihedral angles among the benzene rings and the pyridine rings of the hydrazone ligands are 3.4(5)° and 20.9(5)° for 1, and 7.4(3)° and 19.5(3)° for 2
Summary
Schiff bases are readily synthesized by the condensation reaction of aldehydes with primary amines, which have been widely investigated for their antibacterial and antitumor activities.[1] The metal complexes of Schiff bases have received much attention due to their contribution to the development of coordination chemistry related to catalysis and enzymatic reactions, magnetism and molecular architectures,[2] as well as biological activities.[3] The Schiff bases 4-methoxybenzoic acid (1-pyridin-2-ylmethylidene)hydrazide (HLa; Scheme 1) and benzoic acid (1-pyridin-2-ylethylidene)hydrazide (HLb; Scheme 1) are interesting tridentate hydrazone-type ligands, which possess potential antibacterial activities.[4] In this paper, two new mononuclear zinc(II) complexes, [Zn(La)2] (1) and [Zn(Lb)2] (2), have been synthesized and structurally characterized. The antibacterial activities against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Pseudomonas fluorescens, were evaluated for the complexes.
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