Abstract
We prospectively followed the neurodevelopmental (ND), hearing and pulmonary outcomes of 30 survivors (GA 31-42 wks) treated with inhaled nitric oxide (iNO). They met echocardiographic and clinical criteria for severe persistent pulmonary hypertension (PPHN) and were treated with 6 to 20 ppm NO(M = 76 hrs). Diagnoses were meconium aspiration (14), diaphragmatic hernia(1), asphyxia (4), sepsis (11), pulmonary hypoplasia (1), and congenital syndromes (2). Follow-up assessments were by Bayley Scales, auditory brainstem response or behavioral audiometry. The ND outcome was considered normal if both motor (PDI) and mental (MDI) scores were >84, suspect if either PDI or MDI was <84, and abnormal if both were <84. Three infants were lost to follow-up. The evaluations of the remaining 27 infants (median age = 20 mos) are shown below. Table
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