Abstract
BackgroundSeveral studies have reported that oral immunotherapy (OIT) is effective for children with cow’s milk (CM) allergy. These studies reported the efficacy of OIT in terms of desensitization, but did not describe sustained unresponsiveness to CM. The aim of this study was to evaluate the efficacy of the OIT protocol using microwave heated cow’s milk (MH-CM) in terms of 2-weeks-sustained unresponsiveness (2-weeks-SU) and safety.MethodsForty-eight children were enrolled in this study. Thirty-one children agreed to receive rush OIT using MH-CM (the OIT group) and another 17 children who did not want to receive rush OIT formed the untreated group. Rates of desensitization and 2-weeks-sustained unresponsiveness were compared between the two groups at 1 year after the start of OIT. We followed up these rates and safety data for another year and for longer in the OIT group.ResultsNo children in the untreated group did not pass an open food challenge to CM. Of the 31 children in the OIT group, 14 (P = 0.002) achieved desensitization, and 8 (P = 0.036) achieved 2-weeks-SU to CM at 1 year from the start of OIT. Two years after the start of OIT, both the rate of desensitization and the rate of 2-weeks-SU in the OIT group significantly increased compared with the rates at 1 year (P = 0.025 and P = 0.008 respectively).ConclusionsThe rush OIT protocol using MH-CM was effective at inducing 2-weeks-SU s to CM and had a good safety profile in children with CM allergy.Trial registration Approval number: 324, Registered 3 February 2009
Highlights
Several studies have reported that oral immunotherapy (OIT) is effective for children with cow’s milk (CM) allergy
The aim of the present study was to evaluate the sustained unresponsiveness and safety of an OIT protocol using microwave heated cow’s milk (MH-CM) in children with CM allergy compared with an untreated group
After patients had undergone the maintenance phase followed by the rush phase, we evaluated whether patients in the OIT group were desensitized or had sustained unresponsiveness to CM at 1, 2, 3- and 4-year followup
Summary
Several studies have reported that oral immunotherapy (OIT) is effective for children with cow’s milk (CM) allergy. These studies reported the efficacy of OIT in terms of desensitization, but did not describe sustained unresponsiveness to CM. Takahashi et al Allergy Asthma Clin Immunol (2016) 12:44 appears to accelerate the development of unheated-milk tolerance compared to strict avoidance [16]. An explanation of this observation might be that the high temperature reduces allergenicity by destroying conformational epitopes of milk proteins that subsequently it promotes unheated CM tolerance. The aim of the present study was to evaluate the sustained unresponsiveness and safety of an OIT protocol using MH-CM in children with CM allergy compared with an untreated group
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More From: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
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