Abstract
Plaque rupture probably is the most important cause of myocardial infarction. Plaque rupture is thought to be precipitated by proteases that attack a weakened fibrous cap overlying an inflamed atherosclerotic plaque. Obviously, plaque rupture is of major interest for atherosclerosis researchers and a major target for development of therapy in the pharmaceutical and biotechnology industries. See pages 705 and 714 There is an urgent need for good models to study plaque rupture in our laboratories. Studies of gene-targeted mice that model atherosclerosis in humans have led to in-depth understanding regarding the initiation and progression of atherosclerosis. In contrast, studies of plaque activation, rupture, and …
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