Abstract
Abstract 1. 1. Pyruvate kinase (PK) from the trematode Schistosoma mansoni closely resembles PK from rabbit muscle in its response to various purine and pyrimidine nucleoside diphosphates and divalent cations, in its insensitivity to activation by FDP and relative insensitivity to inhibition by ATP and in its somewhat higher affinity for PEP. 2. 2. PK's from the filarial nematodes Litomosoides carinii and Dirofilaria immitis closely resemble PK from rabbit liver in the pattern of their substrate and cofactor specificities, by being strongly activated by FDP and inhibited by ATP, and by showing a relatively lower affinity for PEP. 3. 3. The properties of PK from S. mansoni miracidia were indistinguishable from those of PK from the adult forms, and this was also the case for the PK's from D. immitis microfilariae and adults. 4. 4. The molecular weights of PK's from S. mansoni , D. immitis and rabbit muscle were all around 270,000±10 per cent.
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