Two successful spontaneous pregnancies in a patient with a primary primitive neuroectodermal tumor of the ovary

Abstract

Objective To describe a patient with primary primitive neuroectodermal tumor of the ovary with two successful spontaneous pregnancies. Design Case report. Setting Tertiary center for gynecologic oncology. Patient(s) A 25-year-old woman with two spontaneous pregnancies 5 months after and 2 years after conservative treatment of International Federation of Gynecology and Obstetrics stage IC primary primitive neuroectodermal tumor of the ovary. Intervention(s) Assessment of extraovarian spread with staging laparotomy. Four courses of BEP (bleomysin, etoposide, cisplatin) and, for recurrent disease, six courses of salvage VIP (vinblastin, iphosphamide, mesna, cisplatin) chemotherapy. Main outcome measure(s) Two successful deliveries and no residual ovarian cancer. Results(s) A healthy, normal female infant weighing 3,600 g was delivered by cesarean section at 38 weeks' gestation. Sixteen months later another infant, a healthy, normal male weighing 3,500 g, was delivered by cesarean section at 38 weeks' gestation. No residual cancer was detected at follow-up 12 months after the last delivery. Conclusion(s) Conservative fertility-preserving treatment might be considered in patients with primary primitive neuroectodermal tumor of the ovary. Without any assisted reproductive technologies, spontaneous pregnancies might occur.