Two Statistical Methods to Analyze the Role of CHA2DS2VASc Score in Patients with STEMI

Abstract

The CHA2DS2VASc score includes risk factors for coronary artery disease. The aim of this study is to show that the CHA2DS2VASc score calculated at the time of hospital admission may predict mortality and major adverse cardiovascular and cerebrovascular events (MACCE) in-hospital and at 30-day follow-up for patients with STEMI, who were subjected to primary percutaneous coronary intervention (p-PCI). A retrospective cohort study was performed at University Hospital Center ‘Mother Teresa’, in the Cardiology Department between June 2021 and September 2021. The CHA2DS2VASc score was calculated at the time of hospital admission for all of them. The study population was divided into 3 groups according to the CHA2DS2VASc score at the time of admission. A statistical control of result of hospital MACCE was done. As the result of multivariable analysis, smoking and CHA2DS2VASc groups were found to be independent MACCE predictors. The chances of developing MACCE were approximately 5 times higher in a patient of the third CHA2DS2VASc group, compared to that of the first group. CHA2DS2VASc groups are important to define the likelihood that MACCE will occur in patients with ascending STEMI who had undergone PCI. The ROC plot provided a visual representation of the accuracy of CHA2DS2VASc in predicting reinfarction and stroke. AUC 0.852 (95% C.I: 0.776-0.928) showed when CHA2DS2VASc has this predictive ability for morbidity and mortality. CHA2DS2VASc ≥ 4 can be used to determine risk of reinfarction and stroke.