Two-state and continuous phase transitions in lipid bilayers A time-resolved X-ray diffraction study

Abstract

Abstract Structural changes associated with transition from one phase to another have been examined in several lipid-water systems using time-resolved X-ray diffraction methods. Two types of transition mechanism can be recognized on the basis of scattering originating from the packing of the hydrocarbon chains. Two-state transitions are characterized by coexistence of the wide-angle scattering patterns of the initial and final phases throughout the transition region. Continuous transitions, on the other hand, take place through a series of intermediate states that are believed to arise from deformation of the hydrocarbon chain lattice as one phase transforms into another. Two-state processes are observed as subgel to liquid crystal transitions, and continuous transformations are typical of subgel to gel phase transitions. Examples of these transition types are presented and other transitions that do not appear to conform to either of these mechanisms are described.