Two-Stage Analysis on Models for Quantitative Differentiation of Early-Pathological Bladder States

Nina Kalyagina,Victor Loschenov,Tatiana Savelieva,Christian Daul,Didier Wolf,Walter Blondel

doi:10.1155/2014/230829

Abstract

A mathematical simulation method was developed for visualization of the diffuse reflected light on a surface of 3-layered models of urinary bladder wall. Five states, from normal to precancerous, of the urinary bladder epithelium were simulated. With the use of solutions of classical electrodynamics equations, scattering coefficientsμsand asymmetry parametersgof the bladder epithelium were found in order to perform Monte Carlo calculations. The results, compared with the experimental studies, has revealed the influence of the changes in absorption and scattering properties on diffuse-reflectance signal distributions on the surfaces of the modelled media.

Highlights

Laser light wave, penetrated into a biological tissue, changes its direction and intensity in a unique way due to the medium specific optical properties: density and structure, absorption, and concentration of the scattering elements inside the tissue
In order to perform the quantitative differentiation between the bladder early-pathological states, the raw signals from both, experimental and mathematical simulations, were normalized between 0 and 1
The results show a positive correlation for all the five bladder tissue states

Summary

Introduction

Laser light wave, penetrated into a biological tissue, changes its direction and intensity in a unique way due to the medium specific optical properties: density and structure, absorption, and concentration of the scattering elements inside the tissue. Described techniques [4, 5] for analysis of the DR light distributions, based on the irradiation of a tissue by a narrow collimated coherent laser beam and collection of a surface backscattered nonpolarized light signal by a photodetector, showed that such an approach allows for detecting differences in light signals according to the optical properties tissues and tissue phantoms and can be applied in vivo for internal organs, such as urinary bladder (UB). This principle will be used in our study

Methods

Results

Conclusion