Abstract
BackgroundsPrevious studies suggest that miR-146a rs2910164 and miR-499 rs3746444 polymorphisms are associated with susceptibility to pulmonary tuberculosis, but the reported findings are inconsistent. We conducted this meta-analysis to evaluate the relationships between the two single nucleotide polymorphisms and tuberculosis. MethodsPotentially relevant studies were identified by searching PubMed and Embase databases in addition to manual searches of references of retrieved full publications. The summary odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a random-effect model. ResultsA total of 4 reports containing 5 independent studies were included in this meta-analysis. Neither miR-146a rs2910164 polymorphism nor miR-499 rs3746444 polymorphism was found to be associated with pulmonary tuberculosis. Studies with different ethnicities are needed to confirm our findings. ConclusionsThis meta-analysis suggests that miR-146a rs2910164 polymorphism and miR-499 rs3746444 polymorphism are not associated with pulmonary tuberculosis.
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