Abstract
Fulminant hepatitis is a rare complication of acute hepatitis A infection. Nevertheless, the seroepidemiology of the infection is rapidly changing with the developing world, rendering more adults susceptible to the infection, in particular with more severe course. We report here fulminant hepatitis A infection with a mortal course during an epidemic period in two siblings. Although it causes a self-limited mild disease, hepatitis A virus may have a severe course including fulminant hepatitis and may lead to mortality, especially in older ages. Hence, the risk of hepatitis A virus infection and its complications should be reduced with measures of immunization and sanitation.
Highlights
Hepatitis A virus (HAV) is the most common cause of viral hepatitis
Considering the hepatitis viruses, hepatitis B virus is the most common etiologic factor followed by hepatitis A virus
The rate of Fulminant hepatitis (FH) during the course of the hepatitis A infection may increase with the presence of underlying disease like chronic hepatitis B and C infections [14,17]
Summary
Summary: Fulminant hepatitis is a rare complication of acute hepatitis A infection. The seroepidemiology of the infection is rapidly changing with the developing world, rendering more adults susceptible to the infection, in particular with more severe course. We report here fulminant hepatitis A infection with a mortal course during an epidemic period in two siblings. It causes a self-limited mild disease, hepatitis A virus may have a severe course including fulminant hepatitis and may lead to mortality, especially in older ages. The risk of hepatitis A virus infection and its complications should be reduced with measures of immunization and sanitation
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