Abstract
Adenoid cystic carcinoma (ACC) is a relatively rare salivary gland malignancy, exhibiting a lethal clinical course often several years after initial diagnosis. It is rarely found outside major or minor salivary glands especially as a bone lesion. Here, 2 rare clinical conditions of ACC arising from the parotid gland and spreading into the mandible are presented. A 50-year-old woman and 49-year-old man presented with pain and paresthesia in the left face. A swelling was observed and computed tomography detected an osteolytic lesion with irregular margins in the mandible. Clinical diagnosis included osteomyelitis and sarcoma. Tumors presented as solid masses with few ductiform structures and exhibited perineurial invasion in the inferior alveolar nerve and high-grade transformation. Challenges in the diagnosis of ACC highlight the need for meticulous clinical management in an effort to allow for early detection of the primary tumor and initiation of the appropriate therapy.
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