Abstract
Survival of heart failure patients depends on several factors including the etiology of the disease and the modality of its treatment. However, a significant component of the variability of heart failure phenotype is due to differences in the genetic background of patients. To identify the genes that modify the outcome of the disease, we have used an experimental model of heart failure induced by cardiac specific overexpression of calsequestrin (CSQ) in mice. CSQ overexpression leads to a dilated cardiomyopathy with a strong strain-specific variability and this model can be used to identify quantitative trait loci (QTL) modifying heart failure phenotype.
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