Abstract

Dan Heller and William Dunbar call their molecular detection start-up Two Pore Guys because the firm’s technology relies on silicon nitride nanopores and because they thought the name was funny. Heller, a computer scientist with an entrepreneurial streak, and Dunbar, a former computer engineering professor at the University of California, Santa Cruz, can afford to joke around. In April, their six-year-old company raised $24.5 million from the savvy Silicon Valley investor Vinod Khosla. Heller and angel investors previously kicked in about $7 million. With the newly raised funds, Two Pore Guys hopes to get its handheld detector and disposable nanopore-enabled test strips into the hands of assay developers next year. Those developers will use Two Pore Guys’ hardware to design rapid, low-cost tests for viruses such as HIV and Zika, food-borne pathogens, and environmental contaminants. A vote of confidence came last month from Monsanto, which agreed to evaluate the firm’s

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