Abstract
The ability of neuron to change and maintain biochemical signaling, shape and the size of synapses in response to stimuli is known as synaptic plasticity, which is believed to be the cellular basis for learning and memory. Recent advance in studying synaptic plasticity is 2-photon Fluorescence Lifetime Imaging Microscopy (2pFLIM), which enables the visualization of the activity and oligomerization of signaling molecules at the level of single synapse in neurons. Here we introduce the recent results of the imaging of CamKII and Ras activation in single dendritic spines in brain tissue.
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