Abstract
Two novel water soluble heteroglycan (PCp-I and PCp-II) with anti-A549 lung cancer cells activity were isolated from Psoralea corylifolia L. Their average molecular weights were 2.721 × 104 and 2.850 × 104. PCp-I and PCp-II had the same monosaccharide composition, but their molar ratios were different. Based on methylation and NMR spectroscopy, the part structure of PCp-I was identified. The results of scanning electron microscope (SEM) showed that PCp-I had an irregular porous structure and PCp-II was flaky and irregularly curved. The results of thermogravimetry-differential scanning calorimetry (TG-DSC) showed that PCp-I and PCp-II had good thermal stability. Furthermore, PCp-I and PCp-II exhibited significant anti-A549 lung cancer cells activity (IC50 = 64.84 and 126.30 μM) in vitro.
Highlights
Polysaccharides, as an important carbohydrate in nature, are from different sources, such as plant, fungi, and algae, and they exhibit different chemical and biological activities, depending on the structure and nature of the monosaccharides [1]
Psoralea corylifolia L. (PC), belonging to Leguminosae, is one of the most popular traditional Chinese medicines used for psoriasis and vitiligo [8,9]
DEAE-52 cellulose cellulose column column chromatography, eluted stepwise with ultra-pure water and different concentrations of aqueous sodium chromatography, eluted stepwise with ultra-pure water and different concentrations of aqueous chloride, respectively, and ultra-pure water eluate waseluate pooledwas as PC-I
Summary
Polysaccharides, as an important carbohydrate in nature, are from different sources, such as plant, fungi, and algae, and they exhibit different chemical and biological activities, depending on the structure and nature of the monosaccharides [1]. Inrecent years, due to its high molecular weight, polysaccharides have poor water solubility, so there has been increasing interest in water-soluble polysaccharides as an important class of bioactive substances that may compete with traditional polysaccharides due to their potential biological activities and processing properties. Phytochemical researches show that P. corylifolia contains coumarins, flavonoids, and monoterpene phenols [10,11]. Yang G and Molecules 2019, 24, 3733; doi:10.3390/molecules24203733 www.mdpi.com/journal/molecules
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