Abstract
Two novel milbemycin derivatives, 5,27-epoxy-13α-hydroxy milbemycin β11 (1) and 5,27-epoxy-13α-hydroxy-25-ethyl milbemycin β11 (2), were isolated from the genetically engineered strain Streptomyces avermitilis AVE-H39. Their structures were elucidated through the interpretation of HR-ESIMS and extensive NMR spectroscopic data. Compounds 1 and 2 exhibited moderate acaricidal and nematicidal activities.
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