Abstract
In this article, two nickel complexes of 2-acetylpyrazine thiosemicarbazone formulated as [Ni(L1)2]·CH3OH (1) and [Ni2(L2)3]ClO4·C2H5OH (2) (HL1 = 2-acetylpyrazine N4-methylthiosemicarbazone, HL2 = 2-acetylpyrazine N4-dimethylthiosemicarbazone), have been synthesized and structurally characterized. The antibacterial activities of the two complexes and ligands were studied. It is found that the ligand HL2 and its corresponding complex displayed effective antimicrobial activity against the tested bacterial. Besides, the growth inhibition assays indicated that complex 2 and the two proligands are capable of showing inhibitory activity against the human hepatocellular carcinoma HepG2 cells, and the subsequent toxicity study on normal QSG7701cells showed that complex 2 has the highest tumor cells selectivity, and its IC50 values is 7.21 times higher than in HepG2 cells.
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