Abstract
In the search for novel anti-infectives from natural sources, fungi, in particular basidiomycetes, have proven to still harbor so much potential in terms of secondary metabolites diversity. There have been numerous reports on isolating numerous secondary metabolites from genus Laetiporus. This study reports on two new triterpenoids, laetiporins C and D, and four known triterpenes from the fruiting body of L. sulphureus. The structures of the isolated compounds were elucidated based on their 1D and 2D nuclear magnetic resonance (NMR) spectroscopic data in combination with high-resolution electrospray mass spectrometric (HR-ESIMS) data. Laetiporin C exhibited weak antifungal activity against Mucor hiemalis. Furthermore, the compounds showed weak antiproliferative activity against the mouse fibroblast L929 and human cancer cell lines, including KB-3-1, A431, MCF-7, PC-3 and A549.
Highlights
Fungi are a valuable group of organisms that have come under a role of study due to their potential for biological activity [1]
This study reports on two new triterpenoids, laetiporins C and D, and four known triterpenes from the fruiting body of L. sulphureus
The structures of the isolated compounds were elucidated based on their 1D and 2D nuclear magnetic resonance (NMR) spectroscopic data in combination with high-resolution electrospray mass spectrometric (HR-ESIMS) data
Summary
Fungi are a valuable group of organisms that have come under a role of study due to their potential for biological activity [1]. Mushroom-forming fungi (mostly belonging to the phylum Basidiomycota) are known to be prolific producers of bioactive secondary metabolites with economic importance [2,3]. Some of these metabolites have potential benefits with emphasis on their anti-Alzheimer, antidiabetic, anti-malarial, anti-microbial, anti-oxidant, antitumor, anti-viral and hypocholesterolemic activities which are important medicinal targets in terms of drug discovery today [3,4,5]. Laetiporus sulphureus, a fungus whose fruiting bodies commonly occur in Germany, was investigated This species is known under its trivial names such as ‘Chicken-of-the-Woods’ or ‘Chicken Mushroom’ [12,13]. The 13C NMR spectroscopic data revealed the presence of 31 carbons signals further identified based on combined analysis of 1D and 1H-13C HSQC spectra as seven methyl groups, eight methylenes, one oxymethylene, four methines, two hydroxymethines, one carboxylic carbon, one olefinic carbon, three non-protonated C-sp hybridized carbons and four quaternary C-sp hybridized carbons (Table 1)
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
