Two new sesquiterpene lactones from the branches and leaves of Cinnamomum camphora chvar. Borneol

Abstract

In this study, two new sesquiterpene lactones, including one eudesmane-type borneolactone B (1), and one germacrane-type borneolactone C (2), and one known analog (3), were isolated from the ethyl acetate extract of the branches and leaves of Cinnamomum camphora chvar. Borneol. The planar structures and absolute configurations of compounds 1 and 2 were elucidated through comprehensive spectroscopic analysis, including one- and two-dimensional NMR, high-resolution mass spectrometry, quantum electronic circular dichroic calculations, and literature comparison. The experimental results show that compounds 1 and 2 possess a rare nitrogen-containing moiety at C-11. These compounds exhibited no obvious inhibitory activity (inhibition rate < 50%) against lipopolysaccharide (LPS)-induced NO production inflammation model in RAW 264.7 macrophages in vitro and against the human hepatocellular carcinoma cell line (HepG2) at the concentration of 20 μM.