Abstract
Two new phenylpropanoids, nicotpanoids A and B (1, 2), were isolated from the leaves of oriental tobacco (a variety of Nicotiana tabacum L.). Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. The two compounds were tested for their cytotoxicity against five human tumor (NB4, A549, SHSY5Y, PC3, and MCF7) cell lines. The results showed that compound 1 had significant inhibitory effect against SHSY5Y cell line with IC50 value of 1.5 1 M. Compound 2 showed notable inhibitory effect against SHSY5Y and MCF7 cell lines with IC50 values of 2.2 and 2.0 1 M, respectively.
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