Abstract
Two Cu(II) complexes, [Cu2(μ-atr)(pydc)2(H2O)4]·5H2O (1) and [Cu(atr)(pydc) (H2O)]·H2O (2), with pyridine-2,6-dicarboxylic acid (H2pydc) and 3-amino-1H-1,2,4-triazole (atr), have been synthesized and characterized. The interaction ability of the both complexes with native calf thymus DNA (CT-DNA) has been monitored as a function of the metal complex-DNA molar ratio. UV–vis spectrophotometry, circular dichroism (CD), thermal denaturation studies, cyclic voltammetry (CV) and viscosity measurements. The intrinsic binding constants Kb of complexes 1 and 2, with CT-DNA obtained from UV–vis absorption studies were 4.7 (±0. 1) × 104 and 9.5 (±0. 1) × 104 M−1, respectively. Further investigation of interaction mode was performed using viscosity, cyclic voltammetry and Tm of CT-DNA studies as well as CD study, indicating complexes bind to DNA via an intercalation mode.
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