Abstract
Two new coordination polymers [Zn (bdc)(bpybzimH2)](DMF)0.5 (1, H2bdc=1,4-dicarboxybenzene, bpybzimH2=6,6′-bis-(1H-benzoimidazol-2-yl)-2,2′-bipyridine, DMF=N,N-dimethylformamide) and [Co (bpybzimH2)(sbc)]H2O (2, H2sbc=4-mercaptobenzoic acid) have been successfully prepared under solvothermal conditions using the multi-N chelating organic ligand bpybzimH2 as the foundational building block. In addition, the Cell Counting Kit-8 assay was conducted to evaluate the anti-proliferation activity of compounds 1 and 2 against human spinal tumor cells OPM-2. The cell viability curves showed that the two compounds have anti-proliferation activity on spinal tumor cells, and the activity of compound 1 is higher than compound 2. The annexin V-FITC/PI assay and western blot were used to detect the apoptotic percentage of OPM-2 cells incubated with compounds 1 and 2. The YAP protein expression and its role in cell apoptosis were further studied with qRT-PCR, immunoblotting, and flow cytometer.
Highlights
New drugs for the treatment of cancer with better rates of cure and side effects that are less severe are greatly needed since cancer has become one of the most serious diseases that kills millions of people every year [1]
A large variety of coordination compounds based on multi-N donor ligands have been synthesized with interesting biological properties, which could be applied as anticancer reagents against various cancer cells [12,13,14,15]
The Zn (II)-O bond distances were in the range of 1.991 [2] to 1.944(2) Å and the Zn (II)-N bond lengths were in the range of 2.045(3) to 2.382(3) Å, all of which were in the normal range of Zn (II)-based coordination polymers constructed from the H2bdc and N-donor pyridyl ligands [23]
Summary
New drugs for the treatment of cancer with better rates of cure and side effects that are less severe are greatly needed since cancer has become one of the most serious diseases that kills millions of people every year [1]. A large variety of coordination compounds based on multi-N donor ligands have been synthesized with interesting biological properties, which could be applied as anticancer reagents against various cancer cells [12,13,14,15] For these reasons, we decided to synthesize new MOCs by using zinc and cobalt as metal ions in order to study some of the anti-cancer properties or activity exhibited by these materials. We decided to synthesize new MOCs by using zinc and cobalt as metal ions in order to study some of the anti-cancer properties or activity exhibited by these materials On another level, we selected 6,60-bis-(1H-benzoimidazol-2-yl)-2,20-bipyridine (bpybzimH2) as ligand, a scarcely explored molecule for CPs construction, given its potential capacity to fulfill the above-mentioned structural and biological roles [16]. Regarding its coordinating ability in metal-organic architectures, it is necessary to introduce another organic ligand to extend its dimension
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
