Abstract
Two new iridoids, 3-(5-(methoxycarbonyl)-2-oxo-2H-pyran-3-yl)butanoic acid, named verbeofflin I (1), and 7-hydroxydehydrohastatoside (2), were isolated from the aerial part of Verbena officinalis L, along with three known iridoids, verbenalin (3), 3,4-dihydroverbenalin (4), hastatoside (5) by means of various column chromatography steps. The structures of these compounds were elucidated through analysis of their spectroscopic data obtained using 1D and 2D NMR and MS techniques. Verbeofflin I (1) is the new class of secoiridoid in the family Verbenaceae.
Highlights
Verbena officinalis L. is a medicinal herb widely distributed in the southern part of the YellowRiver in China
Iridoids isolated from Verbena species, for example, verbenalin and hastatoside, are characteristic constituents of V. officinalis, and they exhibit various biological
As a part of our ongoing study on quality control of the plant, we investigated the constituents of Herba verbenae, the present study dealt with the isolation and structural elucidation of two new iridoids, verbeofflin I (1) and 7-hydroxydehydrohastatoside (2), together with three known iridoids, verbenalin (3) [11,12], 3,4-dihydroverbenalin (4) [13], and hastatoside (5) [11,12,14]
Summary
Verbena officinalis L. is a medicinal herb widely distributed in the southern part of the Yellow. Iridoids isolated from Verbena species, for example, verbenalin and hastatoside, are characteristic constituents of V. officinalis, and they exhibit various biological. The relative contents of verbenalin and hastatoside are higher than those of other characteristic iridoids in Herba Verbenae [10]. The two compounds are very fit as target constituents for quality control of. As a part of our ongoing study on quality control of the plant, we investigated the constituents of Herba verbenae, the present study dealt with the isolation and structural elucidation of two new iridoids, verbeofflin I (1) and 7-hydroxydehydrohastatoside (2), together with three known iridoids, verbenalin (3) [11,12], 3,4-dihydroverbenalin (4) [13], and hastatoside (5) [11,12,14]. 1 is that the iridoid skeleton ring is opened between C-5 and C-6
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