Abstract
Two new diterpenoids, including a seco-isopimarane type (1) and an abietane type (2), were isolated from Biscogniauxia sp. (71-10-1-1). Their structures, including absolute configurations, were elucidated by NMR spectroscopic analyses, X-ray crystallography, 13C chemical shifts calculations, and ECD calculations. This is the first report of diterpenoids from Biscogniauxia sp. Furthermore, short-term memory enhancement against Alzheimer’s disease (AD), anti-inflammatory, and cytotoxic activities of 1–2 were also evaluated. The results showed that compound 1 exhibited short-term memory enhancement activity against AD.
Highlights
Biscogniauxia sp. belongs to the Xylariaceae family, growing on the bark of trees and shrubs, preferably on dead or dying branches
Combined with the DEPT-135 and HSQC experiment, these carbons can be categorized into four sp2 carbons, three sp3 quaternary carbons, three sp3 methine carbons, seven sp3 methylene carbons, and six methyl carbons
The results showed that compounds 1–2 showed cytotoxic effect on RAW264.7 cells
Summary
Biscogniauxia sp. belongs to the Xylariaceae family, growing on the bark of trees and shrubs, preferably on dead or dying branches. In our previous chemical investigation of a fungal strain of Biscogniauxia sp. (No.71-10-1-1), structurally diverse active meroterpenoids (diisoprenyl-cyclohexene/ane-type) and their dimers with new skeleton were identified (Zhao et al, 2017; Zhao et al, 2019; Zhao et al, 2021), which showed that this strain can produce natural products with rich chemical diversity. Further chemical investigation on this fungal strain was carried out, which led to the isolation of two new diterpenoids, including a seco-isopimarane type (1) and an abietane type (2). Their structures, including absolute configurations, were elucidated by NMR spectroscopic analyses, X-ray crystallography, 13C chemical shifts calculations, and ECD calculations. The results showed that 1 exhibited short-term memory enhancement activity
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