Abstract
Two novel body/face wash gels enriched with emollient ingredients (including dexpanthenol) were developed for the daily care of dry skin. Two similarly designed 2-week studies (N = 42 each) were conducted to assess the biophysical and cosmetic performance of each of the new wash gels in healthy adults with dry skin. Instrumental measurements quantified the effects of the wash gels on stratum corneum (SC) hydration and transepidermal water loss (TEWL) (with and without a previous sodium lauryl sulfate (SLS) challenge) after single and repeated usage. Following single and repeated applications of the face wash gel to facial skin, as well as to dry SLS-undamaged and SLS-damaged skin of the forearm, skin hydration significantly increased. Similarly, after single and repeated usage of the body wash gel to dry SLS-undamaged and SLS-damaged skin of the forearm, skin moisturization increased significantly from baseline; comparisons with control areas provided inconsistent results for SLS-undamaged skin. No effects on TEWL were observed for either product. Both wash gels were well tolerated and the cosmetic performances were appreciated by the subjects. The study results suggest that daily use of the new wash gels was associated with significant skin-moisturizing effects without adversely affecting skin barrier function and repair.
Highlights
Skin cleansers are available worldwide in different forms, such as bars, creams, liquids, or gels, to be applied together with water [1]
The single application of the face wash gel, as well as the following twice-daily treatment induced an increase in the stratum corneum (SC) moisturization status, as reflected by an enhanced electrical capacitance of the skin surface compared with the baseline (p < 0.001 for all comparisons with baseline)
We could not account for spontaneous changes in transepidermal water loss (TEWL) and SC moisturization status, respectively, over the 2-week study period. Both dexpanthenol-containing wash gels investigated in our studies were found to be suitable for the personal care regimen in dry skin conditions
Summary
Skin cleansers are available worldwide in different forms, such as bars, creams, liquids, or gels, to be applied together with water [1]. Soap-based products may cause damage to the stratum corneum (SC) and extensive dryness [2,3,4]. This is of particular relevance for dry skin sufferers because xerotic skin is associated with an already existing reduced skin hydration and damaged SC. The latter leads to deficient barrier function with increased transepidermal water loss (TEWL), thereby fostering the ‘dry skin cycle’ [5,6]. Gentle skin cleansing without further compromising the skin’s natural protective barrier and moisture level is an important element of body/face wash products to be used on a regular basis by dry skin sufferers
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