Abstract
Chemical investigation of the ethanol extract of the aerial parts of Hydrangea macrophylla collected in the Sichuan Province of China resulted in the isolation of two new cyanogenic glucosides. Their structures were elucidated as [(2R)-2-(β-D-glucopyranosyloxy)-2-(3,4-dimethoxy-phenyl)] acetonitrile (1) and {(2R)-2-[α-D-glucopyranosyl(1→6)β-D-glucopyranosyloxy]-2-(3-hydroxy-4-methoxy-phenyl)}acetonitrile (2) on the basis of extensive spectroscopic analysis (1D, 2D NMR and HRESIMS) and chemical studies.
Highlights
Hydrangea macrophylla (Thunb.) Ser., a Saxifragaceae plant, is widely cultivated in many countries, including China and Japan
According to the prior literature, researches concerning food poisoning cases in Japan were able to prove the presence of cyanogenic glycosides in H. macrophylla [10]
In the course of our chemical and pharmacological studies on Hydrangea plants, we tried to examine the chemical constituents from the aerial parts of H. macrophylla and isolated two new cyanogenic glycosides
Summary
Hydrangea macrophylla (Thunb.) Ser., a Saxifragaceae plant, is widely cultivated in many countries, including China and Japan. Pharmacology research has Molecules 2012, 17 demonstrated that these compounds possessed many biological functions, such as antidiabetic [8], antiallergic, antimicrobial activities [2] and protective effect against rat liver injury induced by. Several novel non-cyanogenic cyanoglycosides were isolated from this plant, and these rare non-cyanogenic cyanoglycosides possessed some interesting bioactivities. They were found to enhance the absorption of drugs, vitamins, and nutrients through the gastrointestinal membrane [11]. In the course of our chemical and pharmacological studies on Hydrangea plants, we tried to examine the chemical constituents from the aerial parts of H. macrophylla and isolated two new cyanogenic glycosides,. This paper deals with the structure elucidation of these two new compounds (Figure 1)
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