TWO NEW Co(II)-BASED COORDINATION POLYMERS: CRYSTAL STRUCTURES AND THE LOCAL ANALGESIA ACTIVITY DUE TO REDUCING LOCAL ACETYLCHOLINE CONTENTS

Abstract

Two new Co(II)-based coordination polymers {[Co(L)](DMF)}n (1, H2L = 5-(1H-imidazol-1-yl)isophthalic acid) and {[Co2(L)2(H2O)]·3H2O}n (2) are successfully synthesized by the hydrothermal or solvothermal method. The resulting single crystal X-ray diffraction studies demonstrate that complex 1 presents a 3D 3,6-connected framework with a binuclear Co(II) paddle-wheel cluster as the secondary building unit, while complex 2 displays a 3,3,4,8-connected 3D network structure with the a trinuclear linear Co3(CO2)6 cluster as the secondary building unit. The in vivo local anesthesia activity of compounds 1 and 2 is evaluated via the mice hot plate analgesic experiment. Then, the local content of acetylcholine in mice is measured by the ELISA assay.