Abstract
Two new clerodane-type diterpenes, tinosporins C (1) and tinosporins D (2) were isolated from the stems of Tinospora sagittata (Oliv.), together with three known ones, columbin (3), tinophylloloside (4), and tinospinoside D (5). The structures of these compounds were determined on the basis of spectroscopic data interpretation, with that of the absolute configuration of compound 1 was assigned by experimental and calculated ECD spectra. The cytotoxicity and α-glucosidase inhibitory activities of isolated compounds were evaluated in vitro.
Highlights
Tinospora sagittata (Oliv.) Gagnep belonging to the family Menispermaceae, is a perennial indeciduous creeping vine widely distributed throughout the south of China and found in northern Vietnam [1]
Tinospora are known to be rich in clerodane diterpenes and the isolation of clerodane diterpenoids from T. sagittata has been reported in many different papers [4,5,6,7,8,9]
The ethanol extract residue was suspended in water and partitioned successively with petroleum ether, EtOAc, and n-BuOH
Summary
Tinospora sagittata (Oliv.) Gagnep belonging to the family Menispermaceae, is a perennial indeciduous creeping vine widely distributed throughout the south of China and found in northern Vietnam [1]. Tinospora are known to be rich in clerodane diterpenes and the isolation of clerodane diterpenoids from T. sagittata has been reported in many different papers [4,5,6,7,8,9]. Different plant collection locations have yielded diterpenes with a variety of structures, and some of clerodane diterpenoid lactones showed various bioactivities, such as anticancer [8,10], anti-inflammatory [5], and anti-adipogenic and anti-obesity activities [11]. As part of an ongoing search for novel bioactive compounds, we studied T. sagittata collected in Xiangxi, Hunan Province, China. This paper reports the isolation and identification of two neo-clerodane diterpenes 1 and 2 from the whole plant, as well as their cytotoxic and α-glucosidase inhibitory activities
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