Abstract
Many types of inherited early onset cataract are known in both human and mouse. Here we describe the mapping of two novel dominant cataract loci in the mouse genome.Cataract and curly whiskers, Ccw,maps to Chromosome 4, 3.1 ± 1.1 cM distal to theb(brown) locus.Total opacity 3, To3,maps to Chromosome 7, 7.1 ± 1.8 cM proximal top(pink-eyed dilution). The map positions of two other dominant cataract mutants have now been refined by three-point crosses.Nuclear and posterior polar cataract, Npp,maps to the central part of Chromosome 5, 1.4 ± 0.5 cM distal toWe(dominant spotting-extreme,an allele at theKitlocus), andOpaque secondary fiber cell junctions, Opj,maps to the proximal region of Chromosome 16, 9.1 ± 1.5 cM distal to the markermd(mahoganoid). While there are no obvious candidate genes in the vicinity of theCcw, Npp,andOpjmutations,To3lies remarkably close to the recently mappedLim2locus, which encodes lens intrinsic membrane protein 2, also called MP19.
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