Abstract
Two new polyunsaturated fatty acid ethyl esters, (9Z,12Z,15Z,18Z,21Z)-ethyl tetracosa-9,12,15,18,21-pentaenoate (1) and (10Z,13Z)-ethyl nonadeca-10,13-dienoate (2), were isolated from a re-collection of the red alga Laurencia okamurai Yamada, together with three known analogues, (9Z,12Z)-ethyl nonadeca-9,12-dienoate (3), (Z)-ethyl octadec-13-enoate (4), and (Z)-ethyl hexadec-11-enoate (5). Their structures were elucidated on the basis of detailed spectroscopic analysis, including IR, HR-EI-MS, and 1D and 2D NMR. In in vitro bioassays, all the isolates were evaluated for their antifungal activity against four fungi, including Candida glabrata (537), Trichophyton rubrum (Cmccftla), Cryptococcus neoformans (32609), and Aspergillus fumigatus (07544).
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